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Container Closure Testing

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The container closure system for a drug product provides critical protection for stability and sterility. ARL offers USP <1207> container closure integrity testing (CCIT) on IV bags, syringes, cassettes, and vials. Three types of leaks that can be detected during CCIT include:

  1. Entry of microorganisms
  2. Escape of the product dosage form or entry of liquids or solids
  3. Escape of nitrogen gas or entry of oxygen, water vapor, or air gase